|
| 16:00 Kheybar Khorramabad – Aluminium Arak 2:2 | 2.16 | 2.66 | 3.84 | 1X | 2-0 | U | no |
| 16:00 Malavan – Foolad Khuzestan 2:2 | 2.59 | 2.53 | 3.16 | 2X | 0-2 | U | no |
| 16:00 Tractor Tabriz – Mes Rafsanjan 4:1 | 1.39 | 3.66 | 9.35 | 1 | 2-0 | U | no |
| 16:45 Zob Ahan – Esteghlal PP | 3.30 | 3.05 | 2.09 | 2X | 0-2 | U | no |
| 17:00 Esteghlal Khuzestan – Paykan PP | 2.59 | 2.76 | 2.67 | 2X | 0-2 | U | no |
|
| 18:30 Haras El Hodoud – Kahrbaa Alasmalia 1:2 | 2.82 | 2.80 | 2.51 | 1X | 2-0 | U | no |
| 18:30 Wadi Degla – Ghazl El Mahalla 3:2 | 1.91 | 2.80 | 4.56 | 2X | 0-2 | U | no |
|
| 18:45 Al-Taawon – Al Hazm Rass 2:2 | 1.65 | 3.65 | 4.57 | 1 | 1-0 | U | no |
| 21:00 Al-Hilal Riyadh – Al Feiha 4:1 | 1.10 | 7.60 | 13.70 | 1 | 3-1 | O | no |
| 21:00 Al-Qadisiyah – Al-Ittihad Jeddah 2:1 | 2.08 | 3.66 | 2.89 | X2 | 1-2 | O | yes |
|
| 21:15 P.A.O.K. – Real Betis 2:0 | 2.40 | 3.66 | 3.06 | 1X | 2-1 | U | no |
| 21:15 Bologna 1909 – Celtic 2:2 | 1.79 | 4.00 | 4.83 | 1 | 2-1 | O | no |
| 21:15 Brann – Midtjylland 3:3 | 3.66 | 3.78 | 2.09 | 1X | 2-1 | O | no |
| 21:15 Fenerbahce – Aston Villa 3:0 | 2.43 | 3.64 | 3.04 | X2 | 0-3 | U | no |
| 21:15 Feyenoord – Sturm Graz 3:0 | 1.47 | 5.16 | 7.00 | 1 | 2-1 | O | no |
| 21:15 Freiburg – Maccabi Tel Aviv 1:0 | 1.21 | 7.80 | 16.50 | 1 | 2-1 | O | no |
| 21:15 Malmo – Crvena Zvezda 0:1 | 3.84 | 3.86 | 2.01 | 1X | 2-1 | U | yes |
| 21:15 Viktoria Plzen – Porto 1:1 | 4.55 | 3.63 | 1.92 | 2 | 0-3 | U | no |
| 21:15 Young Boys – Lyon 0:1 | 4.70 | 4.03 | 1.80 | 1X | 2-1 | O | yes |
|
| 21:30 Ismaily – El Mokawloon 1:2 | 3.46 | 2.58 | 2.36 | 1X | 2-0 | U | no |
|
| 23:30 CA Aldosivi – Defensa y Justicia 0:0 | 2.62 | 2.81 | 2.99 | 1X | 2-0 | U | no |
|
| 23:30 Lincoln City – Burton Albion 2:1 | 1.57 | 4.00 | 5.54 | 1 | 2-1 | U | no |
|
| 23:30 Braga – Nottingham Forest 1:0 | 2.90 | 3.30 | 2.73 | 1X | 2-1 | U | no |
| 23:30 Celta – Lille OSC 2:1 | 2.43 | 3.44 | 3.20 | X2 | 0-1 | U | no |
| 23:30 Dinamo Zagreb – FCSB 4:1 | 1.73 | 4.08 | 5.21 | 1 | 2-1 | U | no |
| 23:30 FC Salzburg – Basel 3:1 | 2.36 | 3.93 | 2.96 | 1X | 2-1 | U | yes |
| 23:30 Ferencvarosi – Panathinaikos 1:1 | 2.43 | 3.42 | 3.22 | X2 | 0-1 | U | no |
| 23:30 Nice – Go Ahead Eagles 3:1 | 1.94 | 4.03 | 3.95 | 1 | 2-1 | O | yes |
| 23:30 Rangers – Ludogorets 1945 1:0 | 2.10 | 3.80 | 3.63 | 1X | 2-1 | U | no |
| 23:30 Roma – VfB Stuttgart 2:0 | 2.12 | 3.74 | 3.60 | 1X | 2-1 | O | no |
| 23:30 Utrecht – Genk 0:2 | 3.15 | 3.54 | 2.40 | X2 | 0-3 | U | no |
|
| 02:30 Club Atletico Banfield – Club Atletico Huracan 1:1 | 2.80 | 2.74 | 2.86 | 2X | 0-2 | U | no |
| 02:30 Union de Santa Fe – Platense 0:0 | 2.14 | 2.68 | 4.40 | 1X | 2-0 | U | no |
