|
| 21:15 CS Universitatea Craiova – AC Sparta Prague 1:2 | 3.22 | 3.30 | 2.39 | 1X | 2-1 | U | no |
| 21:15 Skendija – Slovan Bratislava 2:0 | 3.00 | 3.49 | 2.43 | X2 | 1-2 | O | no |
| 21:15 Breidablik UBK – Shamrock Rovers 3:1 | 2.00 | 3.74 | 3.80 | 1 | 2-0 | U | no |
| 21:15 Fiorentina – Dynamo Kyiv 2:1 | 1.49 | 4.62 | 7.02 | 1 | 2-1 | O | no |
| 21:15 Hacken – AEK Larnaca 1:1 | 2.22 | 3.56 | 3.35 | 1X | 2-1 | U | no |
| 21:15 Jagiellonia Bialystok – Rayo Vallecano 1:2 | 3.64 | 3.58 | 2.10 | 2X | 1-2 | U | no |
| 21:15 KF Drita – AZ Alkmaar 0:3 | 8.65 | 5.31 | 1.37 | 2 | 1-2 | O | no |
| 21:15 Noah Yerevan – Legia Warsaw 2:1 | 3.02 | 3.54 | 2.40 | X2 | 1-2 | U | no |
| 21:15 Samsunspor – AEK Athens 1:2 | 2.88 | 3.30 | 2.62 | 1X | 2-1 | U | no |
|
| 21:15 Dinamo Zagreb – Real Betis 1:3 | 3.68 | 3.68 | 2.12 | 2X | 0-2 | U | yes |
| 21:15 Ferencvarosi – Rangers 2:1 | 1.76 | 4.19 | 4.80 | 1 | 2-0 | U | no |
| 21:15 Ludogorets 1945 – P.A.O.K. 3:3 | 3.74 | 3.60 | 2.13 | 1X | 2-1 | U | yes |
| 21:15 Midtjylland – Genk 1:0 | 1.88 | 4.08 | 4.18 | 1 | 2-1 | O | no |
| 21:15 Nice – Braga 0:1 | 3.38 | 3.63 | 2.25 | X2 | 1-2 | U | no |
| 21:15 Sturm Graz – Crvena Zvezda 0:1 | 3.15 | 3.76 | 2.31 | X2 | 0-3 | O | no |
| 21:15 Utrecht – Nottingham Forest 1:2 | 4.70 | 3.89 | 1.83 | 2 | 0-3 | U | yes |
| 21:15 VfB Stuttgart – Maccabi Tel Aviv 4:1 | 1.24 | 7.05 | 14.60 | 1 | 3-1 | O | no |
| 21:15 Young Boys – Lille OSC 1:0 | 5.32 | 4.45 | 1.66 | 1X | 2-1 | O | yes |
|
| 22:30 ABB – Oriente Petrolero 5:2 | 1.85 | 3.62 | 3.52 | 1 | 2-1 | O | yes |
|
| 23:30 Lincoln Red Imps – Sigma Olomouc 2:1 | 6.60 | 4.52 | 1.52 | 1X | 2-1 | O | yes |
| 23:30 Aberdeen – Strasbourg 0:1 | 5.56 | 4.26 | 1.62 | 2 | 0-3 | U | yes |
| 23:30 Hamrun Spartans – Shakhtar Donetsk 0:2 | 8.70 | 5.15 | 1.38 | 2 | 1-2 | O | no |
| 23:30 Kuopion Palloseura – Lausanne-Sport 0:0 | 3.58 | 3.86 | 2.03 | 1X | 2-1 | O | yes |
| 23:30 Lech Poznan – 1. FSV Mainz 05 1:1 | 2.97 | 3.60 | 2.40 | X2 | 1-2 | U | no |
| 23:30 Rakow Czestochowa – Zrinjski 1:0 | 1.57 | 4.26 | 6.24 | 1 | 2-1 | U | no |
| 23:30 Rapid Wien – AC Omonia 0:1 | 2.32 | 3.53 | 3.16 | 1X | 2-1 | U | no |
| 23:30 Rijeka – Celje 3:0 | 2.09 | 3.62 | 3.62 | 1X | 2-1 | U | no |
| 23:30 Shelbourne – Crystal Palace 0:3 | 19.00 | 8.15 | 1.17 | 2 | 1-2 | O | no |
|
| 23:30 Panathinaikos – Viktoria Plzen 0:0 | 1.94 | 3.70 | 4.34 | X2 | 1-2 | U | no |
| 23:30 Basel – Aston Villa 1:2 | 4.72 | 4.37 | 1.74 | 2 | 1-2 | O | yes |
| 23:30 Brann – Fenerbahce 0:4 | 3.31 | 3.60 | 2.29 | 1X | 2-1 | O | no |
| 23:30 Celta – Bologna 1909 1:2 | 2.36 | 3.48 | 3.29 | 1X | 2-1 | O | no |
| 23:30 Celtic – Roma 0:3 | 3.32 | 3.52 | 2.33 | 2X | 1-2 | U | no |
| 23:30 FCSB – Feyenoord 4:3 | 5.37 | 4.50 | 1.65 | 2 | 0-3 | U | yes |
| 23:30 Freiburg – FC Salzburg 1:0 | 1.48 | 5.16 | 6.90 | 1 | 2-1 | O | no |
| 23:30 Lyon – Go Ahead Eagles 2:1 | 1.28 | 6.45 | 13.10 | 1 | 2-1 | O | no |
| 23:30 Porto – Malmo 2:1 | 1.26 | 6.67 | 13.40 | 1 | 2-1 | O | no |
|
| 00:30 Tigres de la UANL – Deportivo Toluca 1:0 | 2.17 | 3.30 | 3.48 | 1X | 2-1 | U | no |
|
| 01:00 Real Oruro – Nacional Potosi 1:2 | 2.20 | 3.78 | 2.56 | 1X | 1-3 | O | yes |
