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| 03:30 Cruzeiro Esporte Clube – Clube Atletico Mineiro : | | |
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| 04:00 Chicago Fire – Cincinnati : | | |
| 04:00 Houston Dynamo – Colorado Rapids : | | |
| 05:00 San Diego – Los Angeles : | | |
| 06:00 Los Angeles Galaxy – Vancouver Whitecaps : | | |
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| 14:00 Bologna 1909 – Cagliari Calcio : | | |
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| 16:30 Bournemouth – Crystal Palace : | | |
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| 16:30 Lille OSC – Le Havre : | | |
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| 16:30 Sassuolo Calcio – Milan : | | |
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| 17:00 St. Pauli – 1. FSV Mainz 05 : | | |
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| 17:30 Levadiakos – Volos NFC : | | |
| 17:30 OFI Crete – Aris : | | |
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| 18:00 Manchester United – Liverpool : | | |
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| 18:30 Metz – AS Monaco : | | |
| 18:45 Auxerre – Angers SCO : | | |
| 18:45 Paris – Stade Brestois 29 : | | |
| 18:45 Strasbourg – Toulouse : | | |
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| 19:00 Borussia Monchengladbach – Borussia Dortmund : | | |
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| 19:30 P.A.O.K. – Olympiacos Piraeus : | | |
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| 19:30 Juventus – Hellas Verona : | | |
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| 21:00 Freiburg – VfL Wolfsburg : | | |
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| 21:30 Aston Villa – Tottenham Hotspur : | | |
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| 21:30 Panathinaikos – AEK Athens : | | |
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| 22:15 Lyon – Stade Rennais : | | |
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| 22:15 Internazionale Milano – Parma : | | |
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| 22:30 Flamengo – CR Vasco da Gama : | | |
| 22:30 Sao Paulo – Bahia : | | |
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| 22:30 New York City – D.C. United : | | |
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| 01:00 Chapecoense – Red Bull Bragantino : | | |
| 01:00 Sport Club Internacional – Fluminense : | | |
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| 01:00 Austin – St. Louis City : | | |
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| 03:00 Mirassol – Corinthians Paulista : | | |
