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| 03:30 Cucuta Deportivo – Internacional de Bogota 1:1 | 2.15 | 3.15 | 3.24 | 1X | 1-0 | U |
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| 03:30 Sporting Kansas City – St. Louis City 1:1 | 3.84 | 4.37 | 1.84 | 2 | 1-2 | O |
| 04:00 Minnesota United – Atlanta United 1:2 | 1.65 | 4.58 | 4.84 | X2 | 0-1 | U |
| 05:00 Colorado Rapids – Los Angeles 1:0 | 2.47 | 3.96 | 2.68 | 1X | 2-1 | O |
| 05:00 Real Salt Lake – Dallas 3:4 | 1.94 | 4.33 | 3.51 | 1 | 2-1 | O |
| 05:00 Seattle Sounders – Austin 1:2 | 1.79 | 4.28 | 4.19 | 1 | 2-1 | O |
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| 05:30 Phoenix Rising – Colorado Springs Switchbacks 3:1 | 2.33 | 3.22 | 2.70 | X2 | 1-2 | U |
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| 06:00 Los Angeles Galaxy – San Jose Earthquakes 1:0 | 2.18 | 4.40 | 2.90 | 1X | 1-0 | O |
| 06:00 Portland Timbers – San Diego 3:1 | 1.99 | 4.54 | 3.26 | 1X | 2-1 | O |
| 06:00 Vancouver Whitecaps – Houston Dynamo 0:1 | 1.55 | 4.73 | 5.78 | X2 | 1-2 | O |
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| 17:30 Bunyodkor – Kokand 1912 0:1 | 2.75 | 3.22 | 2.53 | X2 | 0-1 | U |
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| 17:45 Al-Wakrah – Qatar SC 2:2 | 2.26 | 3.40 | 2.76 | 1X | 1-0 | U |
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| 18:30 KaPa – JIPPO 1:3 | 5.59 | 3.94 | 1.50 | 2 | 1-2 | U |
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| 18:30 Kairat – Anderlecht 0:3 | 3.55 | 3.48 | 2.16 | X2 | 1-2 | O |
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| 18:30 Xorazm Urganch – Lokomotiv Tashkent 1:3 | 3.22 | 3.33 | 2.18 | 1X | 1-0 | U |
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| 19:15 Dinamo Minsk – Torpedo-BelAZ 4:0 | 1.75 | 3.40 | 5.00 | 1 | 2-1 | O |
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| 19:30 Inter Turku – Copenhagen 0:0 | 6.21 | 4.66 | 1.50 | 2 | 1-2 | O |
| 19:30 Lincoln Red Imps – Larne 0:2 | 2.02 | 3.44 | 3.90 | 1X | 2-1 | U |
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| 19:30 Jagiellonia Bialystok – Iberia 1999 4:0 | 1.34 | 5.51 | 9.60 | 1 | 3-0 | U |
| 19:30 Mjallby – FC Salzburg 0:1 | 4.62 | 4.31 | 1.72 | 2 | 1-2 | O |
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| 20:00 Al Rayyan – Lusail 1:0 | 1.26 | 5.50 | 8.05 | 1 | 3-1 | O |
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| 20:30 Vendsyssel – Hillerod 1:0 | 2.33 | 3.52 | 2.78 | 1X | 2-1 | O |
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| 20:30 Gent – Hibernian 0:0 | 1.61 | 4.28 | 5.36 | 1 | 2-1 | O |
| 20:30 Midtjylland – Rijeka 2:0 | 1.57 | 4.24 | 5.85 | 1 | 2-1 | O |
| 20:30 Nordsjaelland – St. Gallen 1:0 | 1.57 | 4.66 | 5.22 | 1 | 2-1 | O |
| 20:30 P.A.O.K. – Brann 1:1 | 1.59 | 4.45 | 5.30 | X2 | 1-2 | O |
| 20:30 Tromso – Brighton & Hove Albion 0:0 | 5.75 | 4.08 | 1.61 | 1X | 2-1 | U |
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| 20:30 Benfica – AGF Aarhus 3:1 | 1.11 | 12.00 | 21.00 | 1 | 4-1 | O |
| 20:30 Crvena Zvezda – Viktoria Plzen 3:0 | 1.78 | 3.98 | 4.60 | X2 | 1-2 | U |
| 20:30 CS Universitatea Craiova – Ararat - Armenia 1:1 | 1.40 | 4.98 | 8.75 | X2 | 1-2 | O |
| 20:30 Kairat – Anderlecht 0:3 | 3.18 | 3.45 | 2.34 | X2 | 0-1 | U |
| 20:30 OFI Crete – CSKA Sofia 3:0 | 2.49 | 3.58 | 2.85 | 1X | 2-1 | U |
| 20:30 Sint-Truidense – AC Omonia 1:0 | 1.97 | 3.82 | 3.82 | 1 | 2-1 | U |
| 20:30 Besiktas – Zalgiris Kaunas 3:0 | 1.10 | 11.20 | 27.00 | 1 | 2-1 | O |
| 20:30 Egnatia – Lillestrom 0:0 | 3.34 | 3.70 | 2.16 | 1X | 2-1 | U |
| 20:30 Lech Poznan – Thun 7:0 | 1.56 | 4.58 | 5.82 | 1 | 2-1 | U |
| 20:30 Trabzonspor – Ferencvarosi 0:1 | 1.68 | 4.21 | 5.04 | X2 | 1-2 | O |
|
| 21:00 KI Klaksvik – Riga FC 0:0 | 3.57 | 3.68 | 2.04 | 2 | 1-2 | O |
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| 21:15 Baltika Kaliningrad – Dynamo Makhachkala 2:1 | 1.84 | 3.54 | 4.78 | 1X | 2-1 | U |
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| 21:15 P.A.O.K. – Brann 1:1 | 1.68 | 3.74 | 5.59 | X2 | 1-2 | U |
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| 21:30 Al Feiha – Al-Hilal Riyadh 0:3 | 11.70 | 6.80 | 1.20 | 2 | 1-2 | O |
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| 21:30 Gornik Zabrze – AS Monaco 2:3 | 5.38 | 4.71 | 1.55 | 1X | 2-1 | U |
| 21:30 KF Drita – Inter Club d'Escaldes 2:2 | 1.71 | 3.98 | 4.86 | 1 | 2-1 | U |
| 21:30 Twente – Qarabag 0:1 | 1.58 | 4.46 | 5.49 | 1 | 2-1 | U |
| 21:30 Vikingur Reykjavik – Borac Banja Luka 1:3 | 1.59 | 4.35 | 5.49 | X2 | 1-2 | O |
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| 21:30 Crvena Zvezda – Viktoria Plzen 3:0 | 1.84 | 4.06 | 4.14 | X2 | 1-2 | U |
| 21:30 OFI Crete – CSKA Sofia 3:0 | 2.80 | 3.26 | 2.72 | 1X | 2-1 | U |
| 21:30 Sint-Truidense – AC Omonia 1:0 | 1.86 | 3.78 | 4.36 | 1 | 2-1 | U |
|
| 21:45 Sion – Ajax 2:4 | 3.91 | 4.34 | 1.80 | 1X | 2-1 | O |
| 22:00 Motherwell – Freiburg 1:3 | 6.92 | 4.84 | 1.45 | 1X | 2-1 | O |
| 22:00 Panathinaikos – Hradec Kralove 2:2 | 1.50 | 4.24 | 7.25 | 1 | 2-1 | U |
| 22:00 Atalanta – Hapoel Tel Aviv 0:0 | 1.15 | 8.30 | 18.00 | X2 | 0-1 | U |
| 22:00 Gent – Hibernian 0:0 | 1.63 | 3.86 | 5.96 | 1 | 2-1 | U |
| 22:00 Lugano – Maccabi Tel Aviv 2:1 | 1.95 | 3.78 | 3.78 | 1X | 1-0 | U |
|
| 22:15 Bastia – Versailles 78 2:3 | 2.24 | 3.20 | 2.93 | 1X | 1-0 | U |
| 22:15 Bourg-en-Bresse Peronnas 01 – Thionville 0:2 | 2.93 | 3.34 | 2.18 | 1X | 1-0 | U |
| 22:15 Concarneau – Villefranche 2:0 | 2.00 | 3.20 | 3.49 | 1 | 1-0 | U |
| 22:15 Fleury 91 – Orleans 0:2 | 2.02 | 3.30 | 3.32 | 1X | 1-0 | U |
| 22:15 La Roche VF – AS Cannes 1:1 | 2.04 | 3.38 | 3.20 | 1X | 1-0 | U |
| 22:15 Le Puy – Amiens SC 1:0 | 2.19 | 3.14 | 3.08 | 1X | 1-0 | U |
| 22:15 Paris 13 Atletico – Valenciennes 2:1 | 3.10 | 2.98 | 2.27 | X2 | 0-1 | U |
| 22:15 Rouen – Quevilly 3:0 | 1.68 | 3.40 | 4.78 | 1 | 1-0 | U |
| 22:15 Stade Malherbe Caen – Aubagne 1:0 | 1.67 | 3.72 | 4.32 | 1 | 1-0 | U |
|
| 22:15 Rangers – Jablonec 1:0 | 1.40 | 4.76 | 8.65 | X2 | 1-2 | O |
| 22:15 Heart of Midlothian – Rapid Wien 2:2 | 2.45 | 3.54 | 2.85 | X2 | 1-2 | O |
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| 22:30 Sheffield Wednesday – Bradford City 0:1 | 2.39 | 3.42 | 2.77 | 1X | 2-1 | U |
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| 22:30 Rayo Vallecano – Deportivo Alaves 1:1 | 2.38 | 3.15 | 3.60 | X2 | 1-2 | U |
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| 22:30 Getafe – Partizan Belgrade 3:1 | 1.32 | 5.09 | 11.40 | X2 | 1-2 | U |
| 22:30 Hajduk Split – Rakow Czestochowa 2:2 | 2.02 | 3.52 | 3.79 | 1X | 1-0 | U |
| 22:30 Shamrock Rovers – Kuopion Palloseura 1:1 | 2.04 | 3.60 | 3.64 | 1 | 2-1 | U |
| 22:30 Braga – Austria Wien 2:0 | 1.37 | 5.25 | 8.35 | 1 | 2-1 | O |
| 22:30 Dinamo City – Pafos 1:1 | 3.96 | 3.56 | 1.97 | 1X | 2-1 | U |
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| 22:30 Benfica – AGF Aarhus 3:1 | 1.13 | 10.50 | 18.50 | 1 | 2-1 | O |
| 22:30 Crvena Zvezda – Viktoria Plzen 3:0 | 2.15 | 3.62 | 3.46 | X2 | 0-1 | U |
