|
| 04:00 CR Vasco da Gama – Fluminense 3:2 | 3.62 | 3.23 | 2.19 | 2X | 0-2 | U | no |
| 04:00 Santos – Sport Club Internacional 1:2 | 2.41 | 3.15 | 3.23 | X2 | 0-1 | O | no |
|
| 05:37 Guadalajara – Leon 5:0 | 1.37 | 4.95 | 7.11 | 1 | 2-1 | O | no |
|
| 14:30 Oleksandriya – Dynamo Kyiv 0:5 | 12.50 | 5.60 | 1.26 | 1X | 3-0 | U | no |
|
| 16:30 Kayserispor – Fatih Karagumruk 1:0 | 1.98 | 3.69 | 3.93 | 1X | 2-1 | U | no |
|
| 19:30 Spartak Varna – Ludogorets 1945 1:5 | 12.10 | 5.65 | 1.23 | 1X | 2-1 | O | no |
|
| 19:30 Metallist 1925 – SC Poltava 2:0 | 1.06 | 7.60 | 24.00 | 1 | 2-1 | O | no |
|
| 20:30 Besiktas – Kasimpasa 2:1 | 1.44 | 5.24 | 6.86 | 1 | 2-1 | O | no |
| 20:30 Konyaspor – Genclerbirligi 1:0 | 1.81 | 3.72 | 4.78 | 1 | 2-1 | U | no |
|
| 21:15 1. FSV Mainz 05 – Sigma Olomouc 2:0 | 1.31 | 5.04 | 11.10 | 1 | 2-1 | U | no |
| 21:15 AEK Athens – Celje 0:2 | 1.28 | 6.16 | 11.80 | 1 | 2-1 | O | no |
| 21:15 AEK Larnaca – Crystal Palace 1:1 | 6.52 | 4.01 | 1.54 | 2 | 1-2 | O | no |
| 21:15 Rakow Czestochowa – Fiorentina 1:2 | 2.62 | 3.42 | 2.64 | 1X | 2-1 | U | no |
|
| 21:15 Freiburg – Genk 5:1 | 1.60 | 4.40 | 6.19 | 1 | 2-1 | O | no |
| 21:15 Lyon – Celta 0:2 | 2.17 | 3.50 | 3.71 | X2 | 1-2 | U | no |
| 21:15 Midtjylland – Nottingham Forest 1:2 | 2.92 | 3.50 | 2.58 | X2 | 1-2 | U | yes |
|
| 22:00 Dinamo Bucuresti – CS Universitatea Craiova 0:1 | 3.14 | 3.04 | 2.35 | 1X | 2-0 | U | no |
|
| 22:30 SD Aucas – Tecnico Universitario 0:1 | 1.71 | 3.44 | 5.13 | 2X | 0-2 | U | no |
|
| 23:30 AC Sparta Prague – AZ Alkmaar 0:4 | 2.36 | 3.58 | 3.04 | 1X | 2-1 | U | no |
| 23:30 Rayo Vallecano – Samsunspor 0:1 | 1.65 | 3.86 | 5.97 | 1 | 2-1 | U | no |
| 23:30 Shakhtar Donetsk – Lech Poznan 1:2 | 2.24 | 3.56 | 3.30 | 1X | 2-1 | U | no |
| 23:30 Strasbourg – Rijeka 1:1 | 1.43 | 4.93 | 7.75 | 1 | 2-1 | O | no |
|
| 23:30 Aston Villa – Lille OSC 2:0 | 1.70 | 4.18 | 5.29 | 1 | 2-1 | U | yes |
| 23:30 Porto – VfB Stuttgart 2:0 | 2.55 | 3.60 | 2.89 | 2X | 0-2 | U | no |
| 23:30 Real Betis – Panathinaikos 4:0 | 1.44 | 4.88 | 8.50 | 1 | 2-1 | O | no |
| 23:30 Roma – Bologna 1909 3:3 | 1.76 | 3.79 | 5.45 | 1 | 2-0 | U | no |
|
| 01:00 Orense Sporting Club – Mushuc Runa 3:2 | 1.91 | 3.38 | 4.00 | 1 | 2-1 | U | no |
|
| 01:30 Gremio Porto Alegrense – EC Vitoria Salvador 2:0 | 1.84 | 3.58 | 4.57 | 1 | 2-1 | O | no |
| 02:30 Flamengo – Clube do Remo 3:0 | 1.14 | 8.85 | 18.00 | 1 | 2-1 | O | no |
|
| 02:30 Sportivo Trinidense – Sportivo Ameliano 1:1 | 2.75 | 2.77 | 2.90 | 2X | 0-2 | U | no |
