|
| 04:00 Club Atletico Lanus – Club Atletico Tigre 0:1 | 2.09 | 2.88 | 4.15 | 1X | 2-0 | U | no |
|
| 04:30 Juarez – Deportivo Toluca 1:2 | 3.49 | 3.40 | 2.03 | 1X | 2-1 | U | no |
| 08:30 Tijuana – Tigres de la UANL 3:0 | 3.46 | 3.52 | 2.00 | 2 | 0-3 | U | no |
|
| 11:15 Macarthur Sydney – Wofoo Tai Po 2:1 | 1.28 | 5.75 | 8.50 | 1 | 2-1 | O | no |
| 13:30 Eastern Sports Club – Gamba Osaka 0:5 | 11.70 | 8.50 | 1.14 | 2 | 1-3 | O | yes |
| 13:30 Pohang Steelers – BG Pathum United 2:0 | 1.82 | 3.32 | 4.47 | 2X | 0-2 | U | no |
| 13:30 Ratchaburi – Nam Dinh 2:0 | 1.85 | 3.46 | 4.07 | 1 | 2-0 | U | no |
| 15:45 Hanoi Police – Beijing Guoan 2:1 | 2.04 | 3.44 | 3.38 | 1X | 2-1 | U | no |
| 15:45 Tampines Rovers – Kaya Iloilo 5:3 | 1.29 | 5.00 | 10.20 | 1 | 2-1 | O | no |
|
| 21:15 Sigma Olomouc – Celje 2:1 | 2.52 | 3.51 | 2.87 | 1X | 2-1 | U | no |
| 21:15 Slovan Bratislava – Rayo Vallecano 2:1 | 4.78 | 3.96 | 1.76 | 2 | 1-2 | O | yes |
| 21:15 AC Omonia – Dynamo Kyiv 2:0 | 2.25 | 3.59 | 3.25 | X2 | 0-1 | U | no |
| 21:15 AZ Alkmaar – Shelbourne 2:0 | 1.18 | 8.05 | 16.50 | 1 | 2-1 | O | no |
| 21:15 CS Universitatea Craiova – 1. FSV Mainz 05 1:0 | 4.46 | 3.72 | 1.86 | 2 | 1-2 | U | yes |
| 21:15 Hamrun Spartans – Lincoln Red Imps 3:1 | 1.76 | 3.95 | 4.78 | 1 | 2-1 | U | no |
| 21:15 Lech Poznan – Lausanne-Sport 2:0 | 1.89 | 4.26 | 3.72 | X2 | 1-2 | O | yes |
| 21:15 Rakow Czestochowa – Rapid Wien 4:1 | 1.92 | 3.51 | 4.42 | X2 | 1-2 | U | no |
| 21:15 Zrinjski – Hacken 2:1 | 2.91 | 3.41 | 2.54 | X2 | 0-1 | U | no |
|
| 21:15 Aston Villa – Young Boys 2:1 | 1.23 | 7.55 | 14.10 | 1 | 3-1 | O | no |
| 21:15 Fenerbahce – Ferencvarosi 1:1 | 1.65 | 4.34 | 5.57 | 1 | 2-1 | O | no |
| 21:15 Feyenoord – Celtic 1:3 | 1.75 | 4.29 | 4.75 | 1 | 2-1 | O | no |
| 21:15 Lille OSC – Dinamo Zagreb 4:0 | 1.58 | 4.60 | 6.13 | 1 | 2-1 | O | no |
| 21:15 Ludogorets 1945 – Celta 3:2 | 5.01 | 3.84 | 1.80 | 2 | 1-2 | O | no |
| 21:15 P.A.O.K. – Brann 1:1 | 1.57 | 4.55 | 6.34 | 1 | 2-1 | O | no |
| 21:15 Porto – Nice 3:0 | 1.44 | 5.01 | 8.30 | 1 | 2-1 | U | no |
| 21:15 Roma – Midtjylland 2:1 | 1.51 | 4.71 | 7.09 | 1 | 2-1 | O | no |
| 21:15 Viktoria Plzen – Freiburg 0:0 | 3.38 | 3.52 | 2.30 | X2 | 1-2 | U | no |
|
| 23:30 Grimsby Town – Tranmere Rovers 1:2 | 1.71 | 3.72 | 4.57 | 1 | 2-1 | U | yes |
|
| 23:30 Legia Warsaw – AC Sparta Prague 0:1 | 2.73 | 3.50 | 2.64 | 2X | 0-2 | U | no |
| 23:30 Aberdeen – Noah Yerevan 1:1 | 2.26 | 3.58 | 3.24 | X2 | 1-2 | U | no |
| 23:30 Breidablik UBK – Samsunspor 2:2 | 5.30 | 4.42 | 1.62 | 1X | 2-1 | O | yes |
| 23:30 Fiorentina – AEK Athens 0:1 | 1.94 | 3.64 | 4.14 | 1 | 2-1 | O | no |
| 23:30 Jagiellonia Bialystok – Kuopion Palloseura 1:0 | 1.47 | 4.78 | 7.12 | 1 | 2-1 | U | no |
| 23:30 KF Drita – Skendija 1:0 | 2.74 | 3.12 | 2.90 | 2X | 0-2 | U | no |
| 23:30 Rijeka – AEK Larnaca 0:0 | 2.28 | 3.52 | 3.25 | 1X | 2-1 | U | no |
| 23:30 Shamrock Rovers – Shakhtar Donetsk 1:2 | 7.60 | 4.86 | 1.44 | 2 | 1-2 | O | yes |
| 23:30 Strasbourg – Crystal Palace 2:1 | 3.86 | 3.58 | 2.03 | 1X | 2-1 | O | yes |
|
| 23:30 Bologna 1909 – FC Salzburg 4:1 | 1.43 | 5.01 | 8.60 | 1 | 2-1 | O | no |
| 23:30 Crvena Zvezda – FCSB 1:0 | 1.47 | 4.86 | 7.65 | 1 | 2-1 | O | no |
| 23:30 Genk – Basel 2:1 | 2.03 | 3.95 | 3.72 | 1X | 2-1 | O | no |
| 23:30 Go Ahead Eagles – VfB Stuttgart 0:4 | 6.34 | 4.86 | 1.53 | 1X | 2-1 | O | yes |
| 23:30 Maccabi Tel Aviv – Lyon 0:6 | 4.66 | 3.97 | 1.82 | 1X | 2-1 | O | yes |
| 23:30 Nottingham Forest – Malmo 3:0 | 1.25 | 6.62 | 15.00 | 1 | 2-1 | O | no |
| 23:30 Panathinaikos – Sturm Graz 2:1 | 1.75 | 3.88 | 5.37 | 1 | 2-0 | U | no |
| 23:30 Rangers – Braga 1:1 | 3.33 | 3.52 | 2.32 | X2 | 1-2 | U | no |
| 23:30 Real Betis – Utrecht 2:1 | 1.39 | 5.21 | 9.40 | 1 | 2-1 | O | no |
|
| 00:00 Club Libertad – General Caballero JLM 2:0 | 1.81 | 3.40 | 4.50 | 1 | 2-1 | O | no |
| 02:30 Deportivo Recoleta – Club Nacional Asuncion 2:2 | 3.51 | 3.32 | 2.07 | 2 | 1-2 | O | yes |
|
| 03:00 Fluminense – Sao Paulo 6:0 | 1.63 | 3.64 | 6.54 | 2X | 0-2 | U | no |
