|
| 04:00 Chicago Fire – Orlando City 3:1 | 2.09 | 3.88 | 3.27 | X2 | 1-2 | O | yes |
|
| 04:30 Pachuca – Tigres de la UANL 1:2 | 2.57 | 3.30 | 2.58 | 1X | 2-1 | U | no |
| 04:30 Queretaro – Guadalajara 1:0 | 5.11 | 3.54 | 1.68 | 1X | 2-0 | U | yes |
|
| 05:30 Sacramento Republic – Charleston Battery 1:0 | 2.49 | 3.28 | 2.62 | 1X | 2-1 | U | no |
|
| 06:00 Portland Timbers – Real Salt Lake 3:1 | 2.24 | 3.62 | 3.14 | 1X | 2-1 | O | no |
|
| 06:30 Atlas Guadalajara – Leon 2:0 | 2.77 | 3.50 | 2.35 | X2 | 0-3 | U | no |
| 06:30 Tijuana – Deportivo Toluca 0:0 | 3.40 | 3.90 | 1.91 | 1X | 2-1 | O | yes |
| 06:35 Club Universidad Nacional – Atletico San Luis 0:1 | 1.78 | 3.72 | 4.14 | 1 | 2-1 | O | yes |
|
| 13:30 Kaya Iloilo – BG Pathum United 0:2 | 5.40 | 3.90 | 1.58 | X2 | 1-2 | U | yes |
| 13:30 Tampines Rovers – Pohang Steelers 1:0 | 6.42 | 4.30 | 1.46 | 2 | 1-3 | U | yes |
| 13:30 Wofoo Tai Po – Beijing Guoan 3:3 | 3.88 | 3.90 | 1.78 | X2 | 1-2 | U | yes |
| 15:45 Bangkok United – Lion City Sailors 1:0 | 2.04 | 3.58 | 3.26 | 1X | 2-1 | O | no |
| 15:45 Hanoi Police – Macarthur Sydney 1:1 | 1.87 | 3.86 | 3.54 | 1 | 2-1 | O | yes |
| 15:45 Persib Bandung – Selangor 2:0 | 1.86 | 3.74 | 3.70 | 1 | 2-1 | O | no |
|
| 18:25 Al-Riyadh SC – Al Kholood 1:0 | 2.62 | 3.32 | 2.47 | 1X | 2-1 | U | no |
|
| 18:30 Oulun Luistinseura – KaPa 0:3 | 2.40 | 3.76 | 2.47 | X2 | 0-3 | O | yes |
|
| 18:30 Al Feiha – Al-Taawon 1:2 | 2.75 | 3.04 | 2.53 | 2X | 0-2 | U | no |
|
| 19:00 Turun Palloseura – KTP Kotka 3:0 | 3.10 | 3.28 | 2.27 | X2 | 1-3 | O | no |
|
| 20:00 Hvidovre – HB Koge 3:1 | 1.71 | 3.74 | 4.52 | 1 | 2-1 | U | no |
|
| 20:15 AEK Athens – Aberdeen 6:0 | 1.30 | 5.74 | 10.30 | 1 | 2-1 | O | no |
| 20:15 Breidablik UBK – Kuopion Palloseura 0:0 | 2.08 | 3.83 | 3.34 | 1X | 2-1 | O | no |
| 20:15 Hacken – Rayo Vallecano 2:2 | 4.22 | 3.91 | 1.82 | X2 | 1-2 | U | yes |
| 20:15 KF Drita – AC Omonia 1:1 | 3.78 | 3.68 | 1.98 | X2 | 1-2 | U | yes |
| 20:15 Rapid Wien – Fiorentina 0:3 | 3.36 | 3.58 | 2.15 | 1X | 2-0 | U | yes |
| 20:15 Rijeka – AC Sparta Prague 0:0 | 3.62 | 3.52 | 2.08 | 1X | 2-1 | O | yes |
| 20:15 Shakhtar Donetsk – Legia Warsaw 1:2 | 1.76 | 4.00 | 4.48 | 1 | 2-0 | U | yes |
| 20:15 Skendija – Shelbourne 1:0 | 2.22 | 3.34 | 3.42 | 1X | 2-1 | U | no |
| 20:15 Strasbourg – Jagiellonia Bialystok 1:1 | 1.50 | 4.63 | 6.22 | 1 | 2-1 | O | no |
|
| 20:15 FC Salzburg – Ferencvarosi 2:3 | 2.06 | 3.82 | 3.50 | 1X | 2-1 | O | no |
| 20:15 FCSB – Bologna 1909 1:2 | 5.69 | 3.93 | 1.66 | 1X | 2-0 | U | yes |
| 20:15 Fenerbahce – VfB Stuttgart 1:0 | 2.41 | 3.69 | 2.90 | 1X | 3-0 | O | no |
| 20:15 Genk – Real Betis 0:0 | 3.15 | 3.75 | 2.24 | X2 | 1-2 | U | no |
| 20:15 Lyon – Basel 2:0 | 1.61 | 4.44 | 5.39 | 1 | 2-1 | O | no |
| 20:15 Feyenoord – Panathinaikos 3:1 | 1.61 | 4.36 | 5.49 | 1 | 2-1 | U | no |
| 20:15 Go Ahead Eagles – Aston Villa 2:1 | 7.15 | 4.94 | 1.45 | 1X | 2-1 | O | yes |
| 20:15 Braga – Crvena Zvezda 2:0 | 2.06 | 3.60 | 3.74 | 1 | 2-0 | U | no |
| 20:15 Brann – Rangers 3:0 | 2.09 | 3.68 | 3.56 | 1X | 2-1 | U | no |
|
| 21:30 Al-Najma Unaizah – Al-Ahli Jeddah 0:1 | 11.20 | 6.35 | 1.20 | 2 | 1-2 | O | yes |
|
| 22:30 Exeter City – Plymouth Argyle 2:0 | 2.83 | 3.38 | 2.40 | X2 | 0-3 | U | no |
|
| 22:30 Hamrun Spartans – Lausanne-Sport 0:1 | 5.86 | 4.32 | 1.56 | 1X | 2-0 | U | yes |
| 22:30 1. FSV Mainz 05 – Zrinjski 1:0 | 1.23 | 6.41 | 13.60 | 1 | 2-1 | O | no |
| 22:30 AZ Alkmaar – Slovan Bratislava 1:0 | 1.31 | 5.61 | 9.75 | 1 | 2-1 | O | no |
| 22:30 Crystal Palace – AEK Larnaca 0:1 | 1.18 | 7.35 | 17.50 | 1 | 2-1 | O | no |
| 22:30 CS Universitatea Craiova – Noah Yerevan 1:1 | 1.90 | 3.70 | 4.06 | 1X | 2-1 | U | no |
| 22:30 Lincoln Red Imps – Lech Poznan 2:1 | 15.50 | 7.33 | 1.19 | 2 | 1-2 | O | yes |
| 22:30 Samsunspor – Dynamo Kyiv 3:0 | 2.01 | 3.44 | 3.95 | 1X | 2-1 | U | no |
| 22:30 Shamrock Rovers – Celje 0:2 | 3.66 | 3.66 | 2.02 | 1X | 2-1 | O | yes |
| 22:30 Sigma Olomouc – Rakow Czestochowa 1:1 | 2.91 | 3.31 | 2.52 | X2 | 0-3 | U | no |
|
| 22:30 Freiburg – Utrecht 2:0 | 1.53 | 4.48 | 6.44 | 1 | 2-1 | U | no |
| 22:30 Maccabi Tel Aviv – Midtjylland 0:3 | 3.32 | 3.56 | 2.22 | 1X | 2-1 | U | no |
| 22:30 Malmo – Dinamo Zagreb 1:1 | 3.10 | 3.32 | 2.45 | X2 | 1-2 | U | no |
| 22:30 Celta – Nice 2:1 | 1.84 | 3.76 | 4.48 | 1X | 2-1 | U | no |
| 22:30 Celtic – Sturm Graz 2:1 | 1.54 | 4.58 | 6.09 | 1 | 2-1 | O | no |
| 22:30 Lille OSC – P.A.O.K. 3:4 | 1.65 | 4.13 | 5.44 | 1 | 2-1 | O | no |
| 22:30 Young Boys – Ludogorets 1945 3:2 | 1.84 | 3.70 | 4.58 | 1 | 2-0 | U | no |
| 22:30 Nottingham Forest – Porto 2:0 | 2.66 | 3.24 | 2.88 | 2X | 0-2 | U | no |
| 22:30 Roma – Viktoria Plzen 1:2 | 1.36 | 5.39 | 9.05 | 1 | 2-1 | O | no |
