|
| 03:30 Birmingham Legion – North Carolina 1:1 | 2.29 | 3.28 | 2.94 | 1X | 1-0 | U | yes |
| 06:00 Sacramento Republic – Orange County Blues 2:1 | 1.71 | 3.58 | 4.60 | 1 | 2-1 | U | no |
|
| 15:00 Young Lions – Hougang United 0:2 | 4.48 | 4.50 | 1.57 | 1X | 1-3 | O | yes |
|
| 20:15 AC Omonia – 1. FSV Mainz 05 0:1 | 4.05 | 3.78 | 1.88 | X2 | 1-2 | U | yes |
| 20:15 Dynamo Kyiv – Crystal Palace 0:2 | 6.07 | 4.39 | 1.54 | X2 | 1-2 | U | yes |
| 20:15 Kuopion Palloseura – KF Drita 1:1 | 1.65 | 3.92 | 5.51 | 1 | 2-1 | U | yes |
| 20:15 Lausanne-Sport – Breidablik UBK 3:0 | 1.42 | 5.21 | 6.89 | 1 | 2-1 | O | no |
| 20:15 Lech Poznan – Rapid Wien 4:1 | 2.36 | 3.68 | 2.89 | X2 | 0-1 | U | no |
| 20:15 Noah Yerevan – Rijeka 1:0 | 2.18 | 3.52 | 3.34 | 1X | 1-0 | U | no |
| 20:15 Rayo Vallecano – Skendija 2:0 | 1.20 | 6.68 | 16.50 | 1 | 2-1 | O | no |
| 20:15 Jagiellonia Bialystok – Hamrun Spartans 1:0 | 1.23 | 6.43 | 14.10 | 1 | 2-1 | O | no |
| 20:15 Zrinjski – Lincoln Red Imps 5:0 | 1.37 | 5.11 | 8.70 | 1 | 2-1 | O | no |
|
| 20:15 Brann – Utrecht 1:0 | 2.10 | 3.68 | 3.53 | 1X | 1-0 | U | no |
| 20:15 FCSB – Young Boys 0:2 | 2.66 | 3.55 | 2.68 | 2X | 0-2 | U | no |
| 20:15 Fenerbahce – Nice 2:1 | 1.74 | 4.00 | 4.82 | 1 | 2-1 | O | no |
| 20:15 Panathinaikos – Go Ahead Eagles 1:2 | 1.64 | 4.36 | 5.17 | 1 | 2-1 | O | no |
| 20:15 Roma – Lille OSC 0:1 | 1.74 | 3.94 | 4.98 | 1 | 2-1 | O | yes |
| 20:15 Viktoria Plzen – Malmo 3:0 | 1.91 | 3.70 | 4.21 | 1 | 2-0 | U | no |
| 20:15 Bologna 1909 – Freiburg 1:1 | 1.95 | 3.68 | 4.06 | 1X | 1-0 | U | no |
| 20:15 Celtic – Braga 0:2 | 1.89 | 3.92 | 4.06 | X2 | 0-1 | O | no |
| 20:15 Ludogorets 1945 – Real Betis 0:2 | 4.96 | 3.90 | 1.75 | X2 | 1-2 | U | yes |
|
| 20:30 AaB Fodbold – HB Koge 2:1 | 1.45 | 4.75 | 6.20 | 1 | 2-1 | O | no |
|
| 22:30 Rotherham United – Bradford City 2:2 | 3.44 | 3.56 | 2.08 | 1X | 2-1 | U | no |
|
| 22:30 Aberdeen – Shakhtar Donetsk 2:3 | 6.17 | 4.60 | 1.51 | 1X | 2-1 | O | yes |
| 22:30 AC Sparta Prague – Shamrock Rovers 2:0 | 1.28 | 5.57 | 12.60 | 1 | 2-1 | U | no |
| 22:30 AEK Larnaca – AZ Alkmaar 4:0 | 3.30 | 3.54 | 2.19 | 2X | 0-2 | U | no |
| 22:30 Celje – AEK Athens 3:1 | 3.32 | 3.68 | 2.13 | 1X | 1-0 | U | no |
| 22:30 Fiorentina – Sigma Olomouc 2:0 | 1.35 | 5.16 | 9.40 | 1 | 2-1 | O | no |
| 22:30 Legia Warsaw – Samsunspor 2:0 | 1.95 | 3.79 | 3.79 | 1X | 1-0 | U | no |
| 22:30 Slovan Bratislava – Strasbourg 1:2 | 3.81 | 3.77 | 1.95 | X2 | 1-2 | U | yes |
| 22:30 Rakow Czestochowa – CS Universitatea Craiova 2:0 | 1.73 | 3.83 | 4.92 | 1 | 2-0 | U | no |
| 22:30 Shelbourne – Hacken 0:0 | 4.00 | 3.74 | 1.90 | X2 | 1-2 | U | yes |
|
| 22:30 Basel – VfB Stuttgart 2:0 | 3.69 | 4.10 | 1.94 | 1X | 2-1 | O | no |
| 22:30 Feyenoord – Aston Villa 0:2 | 3.12 | 3.51 | 2.34 | 1X | 2-1 | U | no |
| 22:30 Genk – Ferencvarosi 0:1 | 1.77 | 4.21 | 4.40 | 1 | 2-1 | O | no |
| 22:30 Lyon – FC Salzburg 2:0 | 1.64 | 4.32 | 5.22 | 1 | 2-1 | O | no |
| 22:30 Maccabi Tel Aviv – Dinamo Zagreb 1:3 | 2.75 | 3.57 | 2.58 | 1X | 2-1 | U | no |
| 22:30 Porto – Crvena Zvezda 2:1 | 1.52 | 4.56 | 6.44 | 1 | 2-1 | O | no |
| 22:30 Sturm Graz – Rangers 2:1 | 2.06 | 3.74 | 3.60 | 1X | 1-0 | U | no |
| 22:30 Celta – P.A.O.K. 3:1 | 1.74 | 3.96 | 4.87 | 1 | 2-1 | U | yes |
| 22:30 Nottingham Forest – Midtjylland 2:3 | 1.47 | 4.87 | 6.85 | 1 | 2-1 | O | no |
