|
| 18:30 Kuopion Palloseura – Midtjylland 0:2 | 4.17 | 3.76 | 1.83 | X2 | 1-2 | U | no |
|
| 19:00 Lahti – Klubi-04 2:2 | 1.45 | 4.50 | 5.88 | 1 | 2-1 | O | no |
|
| 19:00 Al Rayyan – Al-Duhail 1:0 | 2.74 | 3.95 | 2.15 | X2 | 0-3 | O | no |
|
| 19:30 AC Omonia – Wolfsberger AC 1:0 | 1.77 | 3.98 | 4.43 | 1 | 2-0 | U | no |
| 19:30 Fredrikstad – Crystal Palace 0:0 | 7.65 | 4.96 | 1.41 | 2 | 1-3 | O | no |
| 19:30 Noah Yerevan – Olimpija Ljubljana 3:2 | 1.82 | 3.98 | 4.14 | 1 | 2-1 | O | no |
|
| 20:00 Sigma Olomouc – Malmo 0:2 | 3.14 | 3.72 | 2.23 | 1X | 2-1 | O | no |
|
| 20:30 Besiktas – Lausanne-Sport 0:1 | 1.38 | 5.52 | 7.36 | 1 | 2-1 | O | no |
| 20:30 Rapid Wien – Gyori ETO 2:0 | 1.40 | 5.06 | 7.65 | 1 | 2-1 | O | no |
| 20:30 Rigas Futbola skola – Hamrun Spartans 2:2 | 1.70 | 3.92 | 5.00 | 1 | 2-1 | U | no |
|
| 20:30 Samsunspor – Panathinaikos 0:0 | 2.64 | 3.42 | 2.74 | 1X | 2-1 | U | no |
|
| 21:00 Al Sadd – Al-Gharafa 2:0 | 1.66 | 4.30 | 4.04 | 1 | 3-1 | O | no |
|
| 21:00 CS Universitatea Craiova – Istanbul BFK 3:1 | 2.79 | 3.50 | 2.52 | 1X | 2-1 | O | no |
| 21:00 AZ Alkmaar – Levski Sofia 4:1 | 1.39 | 5.11 | 7.85 | 1 | 1-0 | U | no |
| 21:00 CFR Cluj – Hacken 1:0 | 2.18 | 3.82 | 3.12 | 1X | 2-1 | O | no |
|
| 21:00 Ludogorets 1945 – Skendija 2:1 | 1.35 | 5.14 | 9.65 | 1 | 2-1 | U | no |
| 21:00 P.A.O.K. – Rijeka 5:0 | 1.51 | 4.27 | 7.22 | 1X | 2-0 | U | no |
|
| 21:30 Arda Kardzhali – Rakow Czestochowa 1:2 | 4.24 | 3.41 | 1.95 | 2X | 0-2 | U | no |
| 21:30 Banik Ostrava – Celje 0:2 | 2.08 | 3.96 | 3.25 | 1 | 2-1 | O | no |
| 21:30 Differdange 03 – KF Drita 0:1 | 2.24 | 3.41 | 3.31 | 1X | 2-0 | U | no |
| 21:30 Rayo Vallecano – Neman Grodno 4:0 | 1.18 | 7.01 | 20.00 | 1 | 3-0 | O | no |
| 21:30 AEK Athens – Anderlecht 2:0 | 2.12 | 3.56 | 3.45 | 1X | 1-0 | U | no |
| 21:30 Brondby – Strasbourg 2:3 | 3.04 | 3.32 | 2.43 | 2X | 1-2 | O | no |
| 21:30 Fiorentina – Polissya Zhytomyr 3:2 | 1.26 | 5.96 | 12.00 | X2 | 2-1 | O | no |
|
| 21:30 Dynamo Kyiv – Maccabi Tel Aviv 1:0 | 2.17 | 3.70 | 3.28 | 1X | 1-0 | U | no |
| 21:30 Genk – Lech Poznan 1:2 | 1.46 | 4.94 | 6.77 | 1 | 2-1 | O | no |
| 21:30 Utrecht – Zrinjski 0:0 | 1.40 | 4.63 | 9.65 | 1 | 2-1 | U | no |
| 21:30 Young Boys – Slovan Bratislava 3:2 | 1.75 | 4.18 | 4.42 | 1 | 2-1 | O | no |
| 22:00 FCSB – Aberdeen 3:0 | 1.62 | 4.12 | 5.69 | 1 | 2-0 | U | no |
|
| 22:15 Linfield – Shelbourne 0:2 | 2.33 | 3.32 | 3.21 | 1X | 2-0 | U | no |
| 22:15 Dinamo City – Jagiellonia Bialystok 1:1 | 4.65 | 4.02 | 1.73 | X2 | 1-2 | U | no |
| 22:30 Servette – Shakhtar Donetsk 1:1 | 5.26 | 4.04 | 1.66 | 1X | 2-1 | O | no |
| 22:30 Virtus – Breidablik UBK 1:3 | 2.32 | 8.30 | 2.04 | 2 | 1-3 | U | no |
| 22:30 1. FSV Mainz 05 – Rosenborg 4:1 | 1.35 | 5.57 | 8.25 | 1 | 2-1 | O | no |
| 22:30 Legia Warsaw – Hibernian 2:3 | 1.63 | 4.24 | 5.15 | 1 | 2-1 | O | no |
| 22:30 Shamrock Rovers – Santa Clara 0:0 | 3.80 | 3.31 | 2.10 | 2X | 0-2 | U | no |
|
| 22:30 Braga – Lincoln Red Imps 5:1 | 1.17 | 14.20 | 9.15 | X2 | 1-1 | U | no |
|
| 02:30 Everton de Vina del Mar – Deportes La Serena 3:1 | 1.74 | 3.64 | 4.74 | 1 | 2-0 | U | no |
