|
| 03:30 Libertad Loja – Independiente del Valle 1:3 | 4.07 | 3.57 | 1.84 | 1X | 2-0 | U | yes |
|
| 03:45 Belgrano – Club Atletico Tigre 0:0 | 2.05 | 3.08 | 3.92 | 2X | 0-2 | U | no |
| 03:45 Club Atletico Banfield – Club Atletico Lanus 2:1 | 2.38 | 2.91 | 3.29 | 1X | 2-0 | U | no |
|
| 07:15 Seattle Sounders – Minnesota United 4:2 | 1.59 | 4.36 | 5.77 | 1 | 2-1 | O | yes |
|
| 13:30 Machida Zelvia – Melbourne City 1:2 | 1.43 | 4.71 | 7.27 | 1 | 2-1 | O | no |
| 13:30 Sanfrecce Hiroshima – Gangwon 1:0 | 1.47 | 4.30 | 7.36 | 1 | 2-1 | O | yes |
| 13:30 Seoul – Chengdu Rongcheng 0:0 | 1.89 | 3.70 | 4.01 | 1 | 2-0 | U | no |
| 15:45 Buriram United – Shanghai Port 2:0 | 1.56 | 4.55 | 5.42 | 1 | 2-1 | O | no |
|
| 18:30 Wadi Degla – Haras El Hodoud 1:1 | 1.64 | 3.26 | 5.45 | 2X | 0-2 | U | no |
|
| 19:30 Al Sadd – Al-Ahli Jeddah 1:2 | 4.44 | 4.04 | 1.74 | 2 | 1-2 | O | yes |
|
| 19:30 Dinamo Batumi – Iberia 1999 0:2 | 6.18 | 4.33 | 1.41 | 1X | 2-1 | U | yes |
|
| 19:30 S.C.U. Torreense – Felgueiras 1932 2:0 | 2.20 | 3.22 | 3.24 | 1X | 2-1 | U | no |
|
| 21:00 AmaZulu – Polokwane City 0:1 | 2.35 | 2.72 | 3.28 | 2X | 0-2 | U | no |
| 21:00 Chippa United – Magesi 0:0 | 2.94 | 2.63 | 2.56 | 1X | 2-0 | U | no |
| 21:00 Kaizer Chiefs – ORBIT College 4:1 | 1.42 | 3.64 | 8.25 | 2X | 0-2 | U | no |
| 21:00 Sekhukhune United – Richards Bay 1:1 | 1.89 | 2.84 | 4.60 | 2X | 0-2 | U | no |
|
| 21:15 Napoli – Eintracht Frankfurt 0:0 | 1.69 | 4.40 | 5.07 | 1 | 2-1 | O | no |
| 21:15 Slavia Prague – Arsenal 0:3 | 12.40 | 5.89 | 1.31 | 2 | 1-2 | O | no |
|
| 21:30 El Mokawloon – Smouha 1:1 | 2.91 | 2.67 | 2.55 | 1X | 2-0 | U | no |
| 21:30 ZED – National Bank of Egypt 1:1 | 3.30 | 2.80 | 2.28 | 2X | 0-2 | U | no |
|
| 21:30 Academico de Viseu – Lusitania Lourosa 3:2 | 1.96 | 3.20 | 3.98 | 2X | 0-2 | U | no |
|
| 21:45 Al-Ittihad Jeddah – Al Sharjah 3:0 | 1.47 | 4.70 | 6.39 | 1 | 2-1 | O | no |
|
| 22:30 San Antonio Bulo Bulo – Always Ready 0:1 | 2.81 | 3.48 | 2.19 | 1X | 2-1 | U | yes |
|
| 23:15 Birmingham City – Millwall 4:0 | 1.96 | 3.34 | 3.88 | 2X | 0-2 | U | no |
| 23:15 Bristol City – Blackburn Rovers 0:1 | 2.09 | 3.28 | 3.52 | 1X | 2-1 | U | no |
| 23:15 Charlton Athletic – West Bromwich Albion 1:0 | 2.53 | 3.04 | 2.88 | 2X | 0-2 | U | no |
| 23:15 Derby County – Hull City 2:1 | 2.22 | 3.30 | 3.18 | 1X | 2-1 | U | no |
| 23:15 Ipswich Town – Watford 1:1 | 1.70 | 3.70 | 4.80 | 1 | 2-1 | U | no |
| 23:15 Leicester City – Middlesbrough 1:1 | 2.22 | 3.34 | 3.14 | X2 | 1-2 | U | no |
| 23:15 Oxford United – Stoke City 0:3 | 2.95 | 3.18 | 2.42 | 1X | 2-1 | U | no |
|
| 23:15 Rotherham United – Burton Albion 2:2 | 2.29 | 3.25 | 3.09 | 1X | 2-1 | U | no |
|
| 23:15 Boreham Wood – Aldershot Town 1:0 | 1.44 | 4.33 | 5.74 | X2 | 1-2 | O | no |
| 23:15 Carlisle United – Halifax Town 2:0 | 1.57 | 3.84 | 4.96 | 1 | 2-1 | O | no |
| 23:15 Hartlepool United – Morecambe 1:1 | 1.62 | 4.10 | 4.20 | X2 | 1-2 | O | no |
| 23:15 Rochdale – Scunthorpe United PP | 1.73 | 3.52 | 4.22 | 1 | 2-1 | U | yes |
| 23:15 Yeovil Town – Wealdstone 0:2 | 2.64 | 3.28 | 2.34 | 1X | 2-1 | U | no |
| 23:15 Forest Green Rovers – Tamworth PP | 1.64 | 3.75 | 4.98 | 1 | 2-1 | U | no |
|
| 23:30 Coventry City – Sheffield United 3:1 | 1.56 | 4.25 | 5.25 | X2 | 1-2 | U | no |
|
| 23:30 Atletico Madrid – Royale Union Saint-Gilloise 3:1 | 1.30 | 6.34 | 10.90 | 1 | 2-1 | O | no |
| 23:30 Olympiacos Piraeus – PSV Eindhoven 1:1 | 2.63 | 3.68 | 2.75 | 1X | 2-1 | O | no |
| 23:30 Bodo-Glimt – AS Monaco 0:1 | 2.28 | 4.11 | 3.00 | X2 | 0-3 | O | yes |
| 23:30 Juventus – Sporting Clube de Portugal 1:1 | 1.97 | 3.78 | 4.11 | 1X | 2-1 | U | no |
| 23:30 Liverpool – Real Madrid 1:0 | 2.43 | 4.12 | 2.77 | 1X | 1-3 | O | yes |
| 23:30 Paris Saint-Germain – Bayern Munich 1:2 | 2.60 | 4.11 | 2.58 | 1X | 1-3 | O | yes |
| 23:30 Tottenham Hotspur – Copenhagen 4:0 | 1.48 | 4.83 | 7.42 | 1 | 2-1 | O | no |
|
| 02:30 Nacional Potosi – Club Blooming 3:0 | 1.50 | 4.15 | 5.22 | 1 | 2-1 | O | no |
