|
| 03:30 Club Deportivo El Nacional – Deportivo Cuenca 0:2 | 2.95 | 3.10 | 2.45 | 2X | 0-2 | U | no |
|
| 03:45 Atletico Tucuman – San Lorenzo de Almagro 1:2 | 2.70 | 2.74 | 2.97 | 2X | 0-2 | U | no |
|
| 04:00 Santos – EC Vitoria Salvador 0:1 | 1.65 | 3.86 | 5.71 | 1 | 2-1 | O | no |
|
| 11:15 Melbourne City – Buriram United 2:1 | 2.07 | 3.62 | 3.48 | X2 | 0-1 | U | no |
| 13:30 Chengdu Rongcheng – Darul Takzim 0:2 | 2.78 | 3.62 | 2.43 | 1X | 2-1 | O | no |
| 13:30 Ulsan Hyundai – Sanfrecce Hiroshima 1:0 | 3.40 | 3.56 | 2.12 | 1X | 2-1 | U | no |
| 15:45 Shanghai Port – Machida Zelvia 0:2 | 4.96 | 4.19 | 1.65 | 2 | 1-2 | O | yes |
|
| 17:30 Pyramids – Pharco 2:0 | 1.28 | 4.70 | 11.60 | X2 | 1-2 | U | no |
|
| 18:30 Dila Gori – Gagra 5:0 | 1.36 | 4.25 | 7.80 | 1 | 2-1 | U | no |
|
| 19:30 Shabab Al-Ahli Dubai – Nasaf Qarshi 4:1 | 1.46 | 4.71 | 6.55 | 1 | 2-1 | O | no |
|
| 19:30 Torpedo Kutaisi – Iberia 1999 3:1 | 3.16 | 3.28 | 2.10 | 1X | 2-1 | U | no |
|
| 20:15 Kairat – Pafos 0:0 | 3.08 | 3.34 | 2.55 | 1X | 1-3 | O | no |
| 20:15 Barcelona – Olympiacos Piraeus 6:1 | 1.26 | 6.92 | 12.50 | 1 | 3-1 | O | no |
|
| 21:30 Den Bosch – Helmond Sport 1:0 | 2.29 | 3.62 | 2.78 | 1X | 2-1 | O | yes |
| 21:30 MVV Maastricht – Vitesse 3:2 | 2.40 | 3.62 | 2.59 | 1X | 2-1 | O | no |
| 21:30 Oss – AFC Ajax II 1:1 | 1.97 | 3.78 | 3.32 | 1X | 2-1 | O | yes |
| 21:30 VVV-Venlo – Utrecht II 0:1 | 1.64 | 4.15 | 4.56 | 1 | 2-1 | O | no |
|
| 21:45 Al-Hilal Riyadh – Al Sadd 3:1 | 1.26 | 5.94 | 11.30 | 1 | 3-1 | O | no |
|
| 22:15 Blackburn Rovers – Sheffield United 1:3 | 2.47 | 3.16 | 2.89 | 2X | 0-2 | U | yes |
| 22:15 Derby County – Norwich City 1:0 | 2.47 | 3.15 | 2.89 | 1X | 2-0 | U | no |
| 22:15 Hull City – Leicester City 2:1 | 3.28 | 3.40 | 2.13 | 1X | 2-1 | U | no |
| 22:15 Ipswich Town – Charlton Athletic 0:3 | 1.64 | 3.72 | 5.32 | 1 | 2-1 | U | no |
| 22:15 Millwall – Stoke City 2:0 | 2.29 | 3.18 | 3.18 | 2X | 0-2 | U | no |
| 22:15 Portsmouth – Coventry City 1:2 | 3.90 | 3.70 | 1.85 | X2 | 1-2 | O | yes |
| 22:15 Preston North End – Birmingham City 0:1 | 2.92 | 3.10 | 2.49 | 1X | 2-0 | U | no |
|
| 22:15 Swindon Town – Notts County 2:2 | 2.08 | 3.46 | 3.29 | 1X | 1-0 | U | no |
|
| 22:15 Boston United – Morecambe 0:4 | 1.87 | 3.62 | 3.72 | X2 | 1-2 | U | no |
| 22:15 York City – Boreham Wood 2:2 | 1.79 | 3.75 | 3.91 | 1 | 2-0 | U | no |
| 22:15 Eastleigh – Scunthorpe United 1:1 | 3.30 | 3.32 | 2.10 | 1X | 2-1 | U | no |
|
| 22:15 Partick Thistle – Ayr United 2:1 | 2.10 | 3.22 | 3.40 | 1X | 1-0 | U | no |
| 22:15 Airdrieonians – Dunfermline Athletic 0:4 | 3.23 | 3.20 | 2.18 | 2X | 0-2 | U | no |
|
| 22:30 Bristol City – Southampton 3:1 | 2.52 | 3.35 | 2.65 | 1X | 2-1 | U | no |
|
| 22:30 Reading – Northampton Town 1:0 | 2.02 | 3.44 | 3.54 | 1X | 1-0 | U | no |
|
| 22:30 Newcastle United – Benfica 3:0 | 1.63 | 4.42 | 5.66 | X2 | 1-1 | U | no |
| 22:30 Villarreal – Manchester City 0:2 | 4.70 | 4.29 | 1.76 | 2 | 1-2 | O | yes |
| 22:30 Royale Union Saint-Gilloise – Internazionale Milano 0:4 | 4.95 | 4.06 | 1.76 | 1X | 1-1 | U | yes |
| 22:30 Copenhagen – Borussia Dortmund 2:4 | 4.39 | 3.94 | 1.87 | 1X | 2-0 | U | yes |
| 22:30 PSV Eindhoven – Napoli 6:2 | 3.14 | 3.68 | 2.35 | X2 | 0-3 | O | no |
| 22:30 Arsenal – Atletico Madrid 4:0 | 1.62 | 4.24 | 6.12 | X2 | 1-1 | O | no |
| 22:30 Bayer 04 Leverkusen – Paris Saint-Germain 2:7 | 4.90 | 4.33 | 1.72 | 2 | 1-2 | O | yes |
|
| 01:45 Union de Santa Fe – Defensa y Justicia 3:0 | 1.99 | 3.15 | 4.04 | 2X | 0-2 | U | no |
